Table 7.
Application of normative data to a separate longitudinal sample (n=151). Sensitivity and specificty were calculated at time of clinical diagnosis, based on Clinical Dementia Rating (CDR). Test scores normed using Robust Normal and Combined Samples. Classification accuracy was compared using the McNemar test.
| Cognitive Tests | Normative Sample | −1 SD | −1.5 SD | ||||
|---|---|---|---|---|---|---|---|
| Sens | Spec | Z0 | Sens | Spec | Z0 | ||
| Episodic Memory | |||||||
| WMS-R Logical Memory Immediate | Robust Normals | 0.65 | 0.88 | 0.07 | 0.54 | 0.95 | −0.22 |
| Combined | 0.54 | 0.93 | 0.35 | 0.96 | |||
| WMS-R Logical Memory Delayed | Robust Normals | 0.62 | 0.90 | 0.15 | 0.58 | 0.96 | −0.37 |
| Combined | 0.58 | 0.93 | 0.35 | 0.96 | |||
| WMS Associate Learning | Robust Normals | 0.45 | 0.87 | −0.14 | 0.21 | 0.96 | −0.14 |
| Combined | 0.39 | 0.86 | 0.13 | 0.97 | |||
| FCSRT Total Recall | Robust Normals | 0.71 | 0.88 | 0.14 | 0.58 | 0.93 | 0.07 |
| Combined | 0.71 | 0.90 | 0.58 | 0.94 | |||
| FCSRT Free Recall | Robust Normals | 0.71 | 0.82 | 0.00 | 0.71 | 0.82 | −0.37 |
| Combined | 0.71 | 0.82 | 0.39 | 0.88 | |||
| BVRT Delayed | Robust Normals | 0.61 | 0.58 | 0.34 | 0.39 | 0.78 | 0.33 |
| Combined | 0.39 | 0.78 | 0.26 | 0.93 | |||
| Executive/Visuospatial | |||||||
| Trails A | Robust Normals | 0.39 | 0.71 | 0.07 | 0.26 | 0.84 | 0.14 |
| Combined | 0.34 | 0.74 | 0.21 | 0.88 | |||
| Trails B | Robust Normals | 0.41 | 0.75 | −0.07 | 0.32 | 0.81 | 0.21 |
| Combined | 0.32 | 0.77 | 0.32 | 0.84 | |||
| WMS-R Digit Span Forward | Robust Normals | 0.11 | 0.86 | 0.00 | 0.05 | 0.90 | 0.00 |
| Combined | 0.11 | 0.86 | 0.05 | 0.90 | |||
| WMS-R Digit Span Backward | Robust Normals | 0.21 | 0.86 | 0.00 | 0.05 | 0.99 | −0.49 |
| Combined | 0.21 | 0.86 | 0.05 | 0.92 | |||
| WMS-R Digit Symbol Coding | Robust Normals | 0.59 | 0.68 | 0.00 | 0.35 | 0.80 | 0.21 |
| Combined | 0.43 | 0.73 | 0.19 | 0.89 | |||
| WMS Mental Control | Robust Normals | 0.13 | 0.76 | 0.00 | 0.08 | 0.91 | 0.00 |
| Combined | 0.13 | 0.76 | 0.08 | 0.91 | |||
| WAIS Block Design | Robust Normals | 0.32 | 0.76 | 0.15 | 0.11 | 0.87 | 0.00 |
| Combined | 0.32 | 0.78 | 0.08 | 0.88 | |||
| Language/Semantic | |||||||
| Animal Fluency | Robust Normals | 0.53 | 0.86 | −0.14 | 0.42 | 0.91 | 0.00 |
| Combined | 0.53 | 0.84 | 0.42 | 0.91 | |||
| Vegetable Fluency | Robust Normals | 0.73 | 0.79 | −0.08 | 0.46 | 0.91 | −0.23 |
| Combined | 0.58 | 0.83 | 0.15 | 0.98 | |||
| Word Fluency Letters S&P total | Robust Normals | 0.35 | 0.86 | −0.28 | 0.14 | 0.94 | 0.00 |
| Combined | 0.35 | 0.82 | 0.14 | 0.94 | |||
| Boston Naming Test | Robust Normals | 0.11 | 0.81 | 1.42 | 0.05 | 0.95 | 0.41 |
| Combined | 0.45 | 0.88 | 0.29 | 0.92 | |||
| WAIS Information | Robust Normals | 0.34 | 0.86 | −0.21 | 0.21 | 0.90 | 0.00 |
| Combined | 0.26 | 0.86 | 0.21 | 0.90 | |||
Abbreviations: SD = Standard Deviation, Sens = Sensitivity, Spec = Specificity, Z0 = McNemar test statistic