Table 1.
Associations between maternal B-Pb and birth outcomes modelled with adjusted multivariable fractional polynomial models in ALSPAC
| n | Unstandardised B regression coefficient (95 % confidence interval) | Fit in adjusted mfp model (final powers)a | |
|---|---|---|---|
| Adjusted model | |||
| Birthweight (g) | 3096 | −9.93 (−20.27, 0.41) | 1 |
| Head circumference (cm) | 2741 | −0.03 (−0.06, 0.00) | 1 |
| Crown–heel length (cm) | 2706 | −0.05 (−0.10, 0.00) | 1 |
| Adjusted model with exclusion of values >10 µg/dl | |||
| Birthweight (g) | 3084 | −11.07 (−22.12, 0.18) | 1 |
| Head circumference (cm) | 2732 | −0.04 (−0.07, 0.00) | 1 |
| Crown-heel length (cm) | 2697 | −0.06 (−0.11, 0.00) | 1 |
| Adjusted model for sensitivity analysisb | |||
| Birthweight (g) | 2785 | −8.16 (−18.97, 2.65) | 1 |
| Head circumference (cm) | 2466 | −0.04 (−0.08, 0.01) | 1 |
| Crown–heel length (cm) | 2436 | −0.08 (−0.15, 0.00) | 1 |
mfp multivariable fractional polynomial
aAdjusted for maternal educational attainment, smoking, gestational age (centred at 40 weeks), maternal height and pre-pregnancy weight, and sex of the infant. 1, linear
bExclusion of upper and lower 5 % of B-Pb values