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. 2016 Jun 3;16:352. doi: 10.1186/s12885-016-2385-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic of MM-302, a novel HER2-targeted antibody–liposomal doxorubicin conjugate. MM-302 consists of doxorubicin encapsulated by a liposome that is conjugated to an anti-HER2 scFv antibody via a polyethylene glycol spacer (PEG-DSPE). MM-302 thus directly targets PEGylated liposomal doxorubicin to HER2-overexpressing tumor cells