Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 3;16:352. doi: 10.1186/s12885-016-2385-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Mechanism of action of MM-302. a MM-302 binds to HER2 extracellular subdomain I, whilst trastuzumab binds to subdomain IV. b MM-302 remains in circulation for long periods of time, providing an opportunity to accumulate in tumors via leaky vasculature. Once in the tumor microenvironment, MM-302 binds specifically to tumor cells that overexpress HER2 (>200 000/cell) and undergoes receptor-mediated endocytosis, releasing doxorubicin inside the cell. By contrast, the vasculature of the heart is more intact and prevents extravasation out of the blood vessels. Furthermore, cardiomyocytes express HER2 below the threshold required for uptake; therefore, MM-302 does not inhibit HER2-mediated signaling in cardiomyocytes [34, 35]