Table 3.
Associations between HLA mismatch and early- and late-onset diffuse large B-cell lymphoma
| Antigen | Mismatch number | Early-onset DLBCL (≤ 2 years after transplantation) |
Late-onset DLBCL (> 2 years after transplantation) |
||||
|---|---|---|---|---|---|---|---|
| IRRa | 95% CI | P for trend | IRRa | 95% CI | P for trend | ||
| A | 0 | 1.38 | (0.99–1.92) | 0.0574 | 0.68 | (0.59–0.77) | 0.0120 |
| 1 | 1.12 | (0.83–1.51) | 0.84 | (0.76–0.94) | |||
| 2 | 1.00 | reference | 1.00 | reference | |||
| B | 0 | 1.27 | (0.90–1.78) | 0.1352 | 0.67 | (0.58–0.76) | 0.0148 |
| 1 | 1.19 | (0.89–1.59) | 0.90 | (0.81–0.99) | |||
| 2 | 1.00 | reference | 1.00 | reference | |||
| DR | 0 | 1.07 | (0.76–1.49) | 0.7224 | 0.58 | (0.51–0.66) | 0.0005 |
| 1 | 0.94 | (0.70–1.26) | 0.76 | (0.68–0.84) | |||
| 2 | 1.00 | reference | 1.00 | reference | |||
| A+B+DR | 0 | 1.17 | (0.70–1.94) | 0.1155 | 0.40 | (0.32–0.50) | 0.0003 |
| 1 | 1.31 | (0.71–2.35) | 0.43 | (0.34–0.55) | |||
| 2 | 0.96 | (0.56–1.65) | 0.55 | (0.45–0.66) | |||
| 3 | 0.92 | (0.58–1.48) | 0.56 | (0.47–0.66) | |||
| 4 | 0.99 | (0.64–1.58) | 0.73 | (0.62–0.86) | |||
| 5 | 0.76 | (0.48–1.22) | 0.60 | (0.45–0.80) | |||
| 6 | 1.00 | reference | 1.00 | reference | |||
DLBCL=Diffuse large B-cell lymphoma; IRR=Incidence rate ratio
a
IRRs were calculated as the ratio of incidence rates between each category of mismatch and the reference mismatch category, and were adjusted for sex, age at transplant, race/ethnicity, year of transplant, transplanted organ, and transplant number.