Table 4.
Top associations between HLA antigens and diffuse large B-cell lymphoma
| Antigen | Transplant recipients with DLBCL | Transplant recipients without DLBCL | SIR | IRRa | 95% CI | P value |
|---|---|---|---|---|---|---|
|
| ||||||
| n (%) | n (%) | |||||
|
| ||||||
| Total cohort | 902 | 171,329 | 12.05 | |||
| HLA-A | ||||||
| A28 + A68 + A69 | 115 (12.75) | 20,160 (11.77) | 14.11 | 1.30 | (1.06–1.58) | 0.0099 |
| A03 | 232 (25.72) | 35,116 (20.50) | 14.10 | 1.22 | (1.05–1.42) | 0.0099 |
| A32 | 36 (3.99) | 8,876 (5.18) | 8.43 | 0.68 | (0.48–0.94) | 0.0255 |
| A25 | 18 (2.00) | 4,491 (2.62) | 7.91 | 0.67 | (0.4–1.03) | 0.0911 |
| HLA-B | ||||||
| B38 | 53 (5.88) | 6,680 (3.90) | 16.67 | 1.48 | (1.10–1.93) | 0.0061 |
| B58 | 13 (1.44) | 7,405 (4.32) | 5.13 | 0.47 | (0.26–0.78) | 0.0071 |
| B18 | 100 (11.09) | 14,613 (8.53) | 14.87 | 1.28 | (1.03–1.57) | 0.0210 |
| B48 | 2 (0.22) | 2,000 (1.17) | 2.79 | 0.23 | (0.04–0.72) | 0.0388 |
| B55 | 15 (1.66) | 4,177 (2.44) | 7.56 | 0.58 | (0.34–0.94) | 0.0396 |
| B41 | 10 (1.11) | 3,642 (2.13) | 5.99 | 0.53 | (0.27–0.94) | 0.0482 |
| B70 + B71 + B72 | 37 (4.10) | 8,343 (4.87) | 13.45 | 1.40 | (0.97–1.95) | 0.0584 |
| B63 | 7 (0.78) | 3,109 (1.81) | 5.45 | 0.52 | (0.22–1.01) | 0.0870 |
| B07 | 195 (21.62) | 31,070 (18.13) | 13.54 | 1.15 | (0.97–1.34) | 0.0954 |
| HLA-C | ||||||
| C08 | 21 (2.33) | 8,035 (4.69) | 6.49 | 0.56 | (0.35–0.85) | 0.0098 |
| C12 | 11 (1.22) | 2,245 (1.31) | 20.16 | 1.94 | (0.99–3.40) | 0.0337 |
| C03 + C09 + C10 | 125 (13.86) | 27,215 (15.88) | 10.60 | 0.81 | (0.66–0.98) | 0.0340 |
| HLA-DQ | ||||||
| DQ07 | 98 (15.86) | 29,725 (20.88) | 7.97 | 0.77 | (0.59–0.99) | 0.0481 |
| DQ08b | 64 (10.36) | 15,031 (10.56) | 12.78 | 1.33 | (0.97–1.78) | 0.0678 |
| DQ05b | 92 (14.89) | 22,526 (15.82) | 11.52 | 1.25 | (0.95–1.63) | 0.0968 |
| HLA-DR | ||||||
| DR13b | 96 (15.53) | 29,321 (20.60) | 8.76 | 0.74 | (0.57–0.93) | 0.0144 |
| DR17b | 112 (18.12) | 22,562 (15.85) | 13.76 | 1.23 | (0.96–1.56) | 0.0947 |
DLBCL=Diffuse large B-cell lymphoma; SIR=Standardized incidence ratio; IRR=Incidence rate ratio
a
IRRs were calculated as the ratio of incidence rates between each antigen category and all other antigens combined, and were adjusted for sex, age at transplant, race/ethnicity, year of transplant, transplanted organ, and transplant number.
b
This category includes restricted transplant years reflecting when the split antigen category was in common use (described in supplementary materials).