Table 5.
Associations between HLA zygosity and diffuse large B-cell lymphoma
| Antigen | Zygosity | Transplant recipients with DLBCL | Transplant recipients without DLBCL | SIR | IRRa | 95% CI | P value |
|---|---|---|---|---|---|---|---|
|
| |||||||
| n (%) | n (%) | ||||||
| A | Heterozygous | 771 (85.48) | 146,613 (85.57) | 12.06 | 1.00 | reference | |
| Homozygous | 130 (14.41) | 24,526 (14.32) | 12.04 | 0.95 | (0.75–1.18) | 0.6363 | |
| B | Heterozygous | 822 (91.13) | 156,972 (91.62) | 11.99 | 1.00 | reference | |
| Homozygous | 79 (8.76) | 14,161 (8.27) | 12.83 | 1.09 | (0.82–1.43) | 0.5365 | |
| C | Heterozygous | 277 (30.71) | 61,742 (36.04) | 11.12 | 1.00 | reference | |
| Homozygous | 270 (29.93) | 47,970 (28.00) | 12.06 | 1.00 | (0.82–1.23) | 0.9708 | |
| DQ | Heterozygous | 519 (57.54) | 106,082 (61.92) | 11.34 | 1.00 | reference | |
| Homozygous | 217 (24.06) | 39,244 (22.91) | 12.07 | 0.99 | (0.81–1.19) | 0.8915 | |
| DR | Heterozygous | 759 (84.15) | 146,386 (85.44) | 11.93 | 1.00 | reference | |
| Homozygous | 133 (14.75) | 24,285 (14.17) | 12.31 | 0.99 | (0.79–1.24) | 0.9541 | |
DLBCL=Diffuse large B-cell lymphoma; SIR=Standardized incidence ratio; IRR=Incidence rate ratio
a
IRRs were calculated as the ratio of incidence rates between homozygous versus heterozygous (reference) antigen carriers, and were adjusted for sex, age at transplant, race/ethnicity, year of transplant, transplanted organ, and transplant number.