Table 2.
Response regarding intensity of pain, allodynia, and hyperalgesia following lidocaine versus placebo intravenous infusion. The study included 20 patients who received twice the active (lidocaine) and twice the placebo drug.
| Lidocaine | Placebo | P | |
|---|---|---|---|
| (n = 40) | (n = 40) | ||
| Effect on intensity of pain | |||
| VAS score pretreatment (SD) | 6.23 (1.56) | 5.45 (2.04) | 0.060 |
| VAS score posttreatment (SD) | 1.46 (1.37) | 3.33 (2.02) | <0.001 |
| VAS score at 16:00 (SD) | 1.77 (1.61) | 4.08 (2.33) | <0.001 |
| VAS score at 20:00 (SD) | 2.38 (1.73) | 4.45 (2.36) | <0.001 |
| VAS score at 24:00 (SD) | 2.33 (1.84) | 4.43 (2.15) | <0.001 |
| VAS score at 08:00 next morning (SD) | 2.95 (1.88) | 5.20 (2.55) | <0.001 |
| VAS reduction % pre-/posttreatment (SD) | 76.4 (23.0) | 40.1 (31.9) | <0.001 |
| VAS reduction % pretreatment—16:00 (SD) | 70.5 (27.7) | 21.6 (45.5) | <0.001 |
| VAS reduction % pretreatment—20:00 (SD) | 59.5 (30.3) | 20.2 (42.1) | <0.001 |
| VAS reduction % pretreatment—24:00 (SD) | 61.0 (32.1) | 13.9 (39.1) | <0.001 |
| VAS reduction % pretreatment—next day (SD) | 52.0 (29.6) | −4.0 (56.3) | <0.001 |
| Effect on allodynia | |||
| Reduced mechanical allodynia (%) | 31 (77.5) | 20 (50.0) | 0.011 |
| Reduced thermal allodynia (%) | 18 (45.0) | 7 (17.5) | 0.008 |
| Reduced cold allodynia (%) | 15 (37.5) | 5 (12.5) | 0.010 |
| Effect on hyperalgesia | |||
| Reduced pinprick hyperalgesia (%) | 26 (65.0) | 14 (35.0) | 0.007 |
| Reduced hot hyperalgesia (%) | 22 (55.0) | 7 (17.5) | <0.001 |
| Reduced cold hyperalgesia (%) | 20 (50.0) | 11 (27.5) | 0.039 |
VAS: visual analogue scale; SD: standard deviation.