Table 3.
Polymorphisms of clock genes associated with cancer.
| Gene | SNPs | Variation | Localization | Pathology | Reference |
|---|---|---|---|---|---|
| Clock | rs1801260 | T>C | Chromosome 4; 3′ UTR; Homo sapiens | Colorectal cancer | [32] |
| rs11932595 | A>G | Chromosome 4; intron; Homo sapiens | Breast cancer | [72] | |
| rs7698022 | C>A | Chromosome 4; intron; Homo sapiens | Breast cancer | [73] | |
| rs11932595 | A>G | Chromosome 4; intron; Homo sapiens | Breast cancer | [73] | |
| rs1048004 | G>T | Chromosome 4; 3′ UTR; Homo sapiens | Breast cancer | [73] | |
| rs3805151 | C>T | Chromosome 4; intron-6; Homo sapiens | Breast cancer | [74] | |
| rs11133391 | T>C | Chromosome 4; intron; Homo sapiens | Glioma | [75] | |
|
| |||||
| Per1 | rs2585405 | C>G | Chromosome 17; missense; Homo sapiens | Glioma | [75] |
| rs2289591 | G>T | Chromosome 17; 5′ near gene; Homo sapiens | Prostate cancer | [76] | |
|
| |||||
| Per2 | rs7602358 | G>T | Chromosome 2; intron; Homo sapiens | Prostate cancer | [76] |
| rs934945: | G>A | Chromosome 2; Exon-23; Homo sapiens | Breast cancer | [74] | |
|
| |||||
| Per3 | rs1012477 | G>C | Chromosome 1; 5′ near gene; Homo sapiens | Prostate cancer | [76] |
| rs57875989 | Deletion/insertion | Chromosome 1; 5′ near gene; Homo sapiens | Colorectal cancer, breast cancer Prostate cancer |
[74, 77–81] | |
| rs228669 | T>C | Chromosome 1; CDS; Homo sapiens | Hepatocellular carcinoma | [82] | |
| rs228644 | G>A | Chromosome 1; intron; Homo sapiens | Lung cancer | [83] | |
|
| |||||
| Bmal1 | rs2290035 | T>A | Chromosome 11; intron; Homo sapiens | Breast cancer | [84] |
| rs969485 | G>A | Chromosome 11; intron; Homo sapiens | Breast cancer | [84] | |
|
| |||||
| Cry1 | rs3809236 | C>T | Chromosome 12; 5′ UTR Homo sapiens | Hepatocellular carcinoma | [82] |
| rs1056560 | T>G | Chromosome 12; exon-13 Homo sapiens | Breast cancer | [74] | |
| rs7297614 | C>T | Chromosome 12; 5′ UTR Homo sapiens | Prostate cancer | [85] | |
| rs1921126 | C>T | Chromosome 12; intron Homo sapiens | Prostate cancer | [85] | |
| rs12315175 | T>C | Chromosome 12; 5′ UTR Homo sapiens | Prostate cancer | [85] | |
| rs12315175 | T>C | Chromosome 12; noncoding sequence | Glioma | [75] | |
|
| |||||
| Cry2 | rs11038689 | A>G | Chromosome 11; intron; Homo sapiens | Breast cancer | [84] |
| rs1401417 | C>G | Chromosome 11; intron; Homo sapiens | Breast cancer Prostate cancer |
[79, 84] | |
| rs11038689 | A>G | Chromosome 11; intron; Homo sapiens | Non-Hodgkin's lymphoma | [86] | |
| rs7123390 | G>A | Chromosome 11; intron; Homo sapiens | Non-Hodgkin's lymphoma | [86] | |
| rs1401417 | C>G | Chromosome 11; intron; Homo sapiens | Non-Hodgkin's lymphoma | [86] | |
|
| |||||
| TIM | rs7302060 | T>C | Chromosome 12; intron; Homo sapiens | Breast cancer | [87] |
| rs2291738 | T>C | Chromosome 12; intron; Homo sapiens | Breast cancer | [87] | |
|
| |||||
| ROR-b | rs3750420 | C>T | Chromosome 9; intron; Homo sapiens | Breast cancer | [84] |
| rs3903529 | T>A | Chromosome 9; intron; Homo sapiens | Breast cancer | [84] | |