Table 1.
Activity against promastigotes and intracellular amastigotes of Leishmania infantum, cytotoxicity in peritoneal macrophages from BALB/c and selectivity index of Morinda citrifolia fruit extract treatment and amphotericin B.
| Compounds | IC50 (µg/mL) | CC50 | SI | |
|---|---|---|---|---|
| Promastigote | Intracellular amastigote | J774.G8 | ||
| Morinda citrifolia fruit juice | 260.5 ± 0.044 | 201.3 ± 0.175 | >2000 | >9.9 |
| Amphotericin B | 3.1 ± 0.230 | 0.9 ± 0.121 | 2.7 ± 0.156 | 3.0 |
IC50: inhibitory concentration of 50% parasites. CC50: cytotoxicity concentration of 50% cells. SI: selectivity index. Data are presented as the mean ± SD of three independent experiments realized at least in triplicate.