Table 4.
IC50 and EC50 values of ComAI and its derivatives.
| Compound | MTCC497 | WT | 4SM | 5SM | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC(μM) | EC(μM) | IC(μM) | EC(μM) | IC(μM) | EC(μM) | IC(μM) | EC(μM) | |||||||||
| 50 | 90 | 50 | 90 | 50 | 90 | 50 | 90 | 50 | 90 | 50 | 90 | 50 | 90 | 50 | 90 | |
| ComAI | 3.75 | 13.5 | – | – | 14.9 | – | – | – | 0.39 | 7.5 | – | – | – | 14.8 | – | – |
| ComAI1 | 1.89 | 12.2 | – | – | – | – | – | – | 0.89 | – | – | – | – | 12.4 | – | – |
| ComAI2 | – | 13 | – | – | 11.5 | – | – | – | 1.78 | – | – | – | – | 15 | – | – |
| ComAI3 | 4.22 | 14.9 | – | – | – | – | – | – | – | – | – | – | – | 13.8 | – | – |
| ComAI4 | – | – | – | – | 0.46 | 14 | – | – | 0.41 | 14.5 | – | – | – | 14.5 | – | – |
| ComAI1′ | – | – | – | – | 14.7 | – | – | – | – | 13.5 | – | – | – | 11.5 | – | – |
IC, inhibitory concentration; EC, Eradication Concentration.
Strains used: MTCC 497, standard reference strain obtained from MTCC, IMTECH, Chandigarh, India; WT, A wild type strain obtained from kindly donated by Prof. L. Jeannine Brady, University of Florida, USA.; 4SM, Multidrug resistant clinical isolate; 5SM, Fluoride resistant clinical isolate.