Table 5.
Synergistic activity of selected ligands with Fluoride (F) and Chlorhexidine (CHX).
| F | CHX | F | CHX | F | CHX | F | CHX | F | CHX | F | CHX | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MTCC 497 | FIC | 0.2 (0.05–0.48) | 2.8 (1.4–4.0) | 0.39 (0.05–0.40) | 2.6 (1.6–5.0) | 0.05 (0.01–0.17) | 3.5 (2.7–5.9) | 0.05 (0.02–0.19) | 3.8 (2.0–7.1) | – | – | – | – |
| I | SYN | NI/ANT | SYN | NI/ANT | SYN | ANT | SYN | ANT | – | – | |||
| WT | FIC | 0.01 (0.01–0.05) | 0.6 (0.5–2.2) | – | – | 0.02 (0.01–0.03) | 0.6 (0.5–1.4) | – | – | 0.02 (0.02–0.04) | 0.6 (0.5–2.4) | 0.02 (0.01–0.02) | 0.6 (0.5–2.7) |
| I | SYN | ADD/NI | – | – | SYN | ADD | – | – | SYN | ADD/NI | SYN | ADD/NI | |
| 4SM | FIC | 1.1(0.7–1.45) | 2.7 (0.6–4.5) | 0.52 (0.5–0.6) | 2.4 (0.5–4.2) | 0.28 (0.28–0.32) | 2.2 (0.6–3.9) | – | – | 2.41 (2.1–2.5) | 3.7 (1.1–6.5) | 0.03 (0.03–0.05) | 1.5 (1.2–2.7) |
| I | ADD | ADD/ANT | ADD | ADD/ANT | ADD | ADD/ANT | – | – | IND | NI/ANT | SYN | NI/ANT | |
| 5SM | FIC | 0.08 (0.02–0.1) | 9.8 (2.0–19.7) | 0.2 (0.02–0.1) | 10 (2.6–18.5) | 0.2 (0.1–0.3) | 11.6 (3.7–23.4) | 0.08 (0.02–0.1) | 11.2 (3.2–25.0) | 0.09 (0.02–0.15) | 13.7 (6.8–23.5) | 0.08 (0.02–0.12) | 15.3 (7.8–24.7) |
| I | SYN | ANT | SYN | NI/ANT | SYN | ANT | SYN | ANT | SYN | ANT | SYN | ANT |
FIC model -FIC Index of ≤ 0.5 was defined as synergy (SYN), FICI of >4.0 was defined as antagonism (ANT), and indifference [i.e., no interaction (NI) or Additive effect (ADD)] as a FICI of >0.5–4; I corresponds to Interpretation in the above table.