Skip to main content
. 2016 Jun 6;7:218. doi: 10.3389/fimmu.2016.00218

Figure 1.

Figure 1

The B cell responses during DENV infection. Mosquitoes inoculate DENV mostly intradermally (1); inoculum is a mixture of mature (black circles) and immature (yellow circles) virions. DCs would capture DENV or DENV Ags and enter lymphatics (2) ferrying these Ags to regional DLNs (3). On the other hand, DENV could also reach the DLN via the lymph flow in a putative cell-free manner. Upon arrival into DLNs, viruses can encounter DENV-specific naive B cells and could generate short-lived PCs producing IgMs by a T-cell-independent extrafollicular B cell response (4) or could enter to a T-cell-dependent GC reaction (5). GCs will generate long-lived PCs and MBCs (6), which can produce a mixture of both neutralizing and cross-reactive DENV-specific Abs. These Abs would either neutralize the virus, containing the spread of infection (7) or enhance the infection of other targets cells, according to ADE (8). Cross-reactive non-neutralizing Abs seem to predominate in the memory response by MBCs (9). On the other hand, DENV may infect B cells “directly” either in circulation or in tissues such as in secondary lymphoid organs (10).