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. 2016 Jun 6;6:27358. doi: 10.1038/srep27358

Figure 7. BDNF Is Critical for Engrafted BDNF-NSC-mediated Cognitive Improvements.

Figure 7

(a) ELISA for the secreted BDNF level following ASO BDNF treatment (n = 5 independent experiments). (b) The MWM task-based analysis of the latency for finding the hidden platform (n = 6 per group; *Non-Tg+Vehicle mice vs. Tg+Vehicle mice, #Tg+Vehicle mice vs. Tg+BDNF-NSCs mice). The multiple comparisons test confirmed the significant differences between Tg+Vehicle mice and Non-Tg+Vehicle mice or Tg+BDNF-NSCs mice. (c) Representative search path in the probe trial test. (d) The records of the search time in the target quadrant and the number of crosses of the probe location in the probe trial test (n = 6 per group). (e) The discrimination ratio of the novel object recognition test (n = 6 per group). (f) ELISA for the hippocampal BDNF level (n = 6 per group). All results are presented as the mean ± SEM. * or one symbol represent p < 0.05, ** or two symbols represent p < 0.01, *** or three symbols represent p < 0.001. Statistical analyses by one-way ANOVAs with Tukey’s post hoc tests.