Table 1. Electrophysiological Properties of Transplanted Control-NSC- and BDNF-NSC-derived Neurons Generating One or More APs Upon Current Injection.
| n | Control-NSCs | BDNF-NSCs | pvalue |
|---|---|---|---|
| 16 (from 5 mice) | 19 (from 7 mice) | ||
| Vrest (mV) | −74.7 ± 1.6 | −73.4 ± 1.0 | 0.45 |
| Rinput (MΩ) | 1388 ± 326 | 739 ± 205 | 0.04 |
| C (pF) | 20.1 ± 4.1 | 39.9 ± 6.5 | 0.03 |
| % of cell with APs | 32.5 ± 15.4% | 84.3 ± 10.2% | 0.02 |
| AP threshold (mV)$ | −20.3 ± 1.4 | −38.8 ± 2.4 | 0.001 |
| AP amplitude (mV)$ | 56.4 ± 4.1 | 86.0 ± 8.0 | 0.03 |
| AP half-width (ms)$ | 1.8 ± 0.1 | 1.6 ± 0.1 | 0.60 |
| AHP amplitude (mV)$ | 8.7 ± 1.3 | 15.4 ± 1.2 | 0.01 |
Vrest = resting membrane potential; Rinput = input resistance; C = capacitance. AP = action potential; AHP = afterhyperpolarization. Statistical analyses by the Mann-Whitney test. $Analysis based on the first AP induced by current injection.