Figure 5.
A Comparison of ratio of internalization and IC50 values of each compound. The compound coupled to CHX-A''-DTPA performed best in both assays and may therefore be a promising new compound. B Comparison of internalization ratio and retention time. The linear fit represents the correlation of internalization with increasing hydrophobicity (Pearson R value = 0.60). C Suggested model of action of the CHX-A''-DTPA-coupled ligand at the PSMA receptor. While the urea-based binding motif and the linker region seem to play primarily a crucial role in targeting the tumor, the chelating entity may have an essential part by enhancing internalization of the compound.