Figure 5.

Representation of percentage of α2,3-sialic acid (SA) PSA against either tPSA serum levels up to 40 ng/ml (panel A) or the pathology (panel B). Serum samples from BPH are indicated with white circles, low-risk PCa with a cross, intermediate-risk PCa with a black triangle and high-risk PCa with a black circle. In Scatter dot plot, dotted line indicates the cut off value for discriminating the high-risk PCa from the other three pathologies, the center line in the box represents the median, and the top (Q3) and bottom (Q1), the 75^th and 25^th percentiles, respectively. (C) Comparison of ROC curves for %α2,3-SA, tPSA, and %fPSA. The %α2,3-SA gave the highest AUC value (AUC=0.97) and the cut-off value 30.05 showed the highest sensitivity (85.7%) and specificity (95.5%).