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. 2016 May 24;6(8):1232–1243. doi: 10.7150/thno.14409

Figure 2.

Figure 2

MAPK feedback activation is dependent on the MET receptor. A. Heatmap of differentially expressed genes in DMSO versus erlotinib treated PC9 cells. B. Western blot analysis of ERBB3, INSR, DUSP4 and DUSP6 in erlotinib (1 μM) treated PC9 cells. C. Western blot analysis of EGFR and ERK activation in PC9 cells treated with erlotinib and inhibitors of EGFR, IGF-1R, PDGFR, FGFR or MET (0.5 μM). D. Cell viability assay of PC9 cells in the presence of erlotinib and inhibitors of MET or IGF-1R. Combo, erlotinib combined with IGF-1R or MET inhibitors (0.5 μM). *P<0.05, ANOVA followed by Tukey's post-test. E. PC9 cells were treated for 10 days as indicated and the cells were stained with crystal violet.