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Post-erlotinib human lung tumor biopsies display increased CRAF and NRAS expression compared to pre-treatment specimens. A. Immunohistochemical staining of phospho-ERK, NRAS and CRAF demonstrating increased CRAF and NRAS expression in post-erlotinib tumor sections compared to paired pre-treatment specimens. B. Schematic representation of targeting the MAPK pathway to overcome both adaptive resistance and acquired resistance to EGFR inhibitors.
