Table 2. Patient baseline characteristics stratified according to stroke risk definitions.
| Clinical characteristics | Total population | Truly low risk | European treatment threshold | U.S. treatment threshold | High risk |
|---|---|---|---|---|---|
| Number of patients | 198,697 | 29,174 (15%) | 17,592 (9%) | 35,996 (18%) | 115,935 (58%) |
| Age, mean (IQR) | 75 (65–83) | 55 (47–61) | 66 (60–70) | 71 (65–78) | 81 (75–86) |
| 64–74 years | 148,480 (75) | 0 (0) | 9,952 (57) | 27,731 (77) | 110,797 (96) |
| ≥75 years | 98,998 (50) | 0 (0) | 0 (0) | 11,763 (33) | 87,235 (75) |
| Female sex | 96,529 (49) | 10,120 (35) | 0 (0) | 12,280 (34) | 74,129 (64) |
| Congestive heart failure* | 34,817 (18) | 0 (0) | 1,491 (8) | 2,819 (8) | 30,507 (26) |
| Heart failure | 20,413 (10) | 0 (0) | 294 (2) | 1,068 (3) | 19,051 (16) |
| Left ventricular dysfunction | 30,833 (16) | 0 (0) | 1,409 (8) | 2,575 (7) | 26,849 (23) |
| Hypertension | 74,113 (37) | 0 (0) | 3,972 (23) | 9,337 (26) | 60,804 (52) |
| Diabetes | 23,785 (12) | 0 (0) | 960 (5) | 2,530 (7) | 20,295 (18) |
| Prior thromboembolism* | 32,382 (16) | 0 (0) | 0 (0) | 1,086 (3) | 31,296 (27) |
| Ischemic stroke | 24,230 (12) | 0 (0) | 0 (0) | 793 (2) | 23,437 (20) |
| Systemic embolism | 1,615 (1) | 0 (0) | 0 (0) | 31 (0) | 1,584 (1) |
| Transient ischemic attack | 10,198 (5) | 0 (0) | 0 (0) | 354 (1) | 9,844 (8) |
| Vascular disease* | 37,045 (19) | 0 (0) | 1,217 (7) | 3,360 (9) | 32,468 (28) |
| Myocardial infarction | 25,768 (13) | 0 (0) | 938 (5) | 2,469 (7) | 22,361 (19) |
| Aortic plaque | 353 (0) | 0 (0) | 7 (0) | 28 (0) | 318 (0) |
| Peripheral vascular disease | 15,153 (8) | 0 (0) | 320 (2) | 1,098 (3) | 13,735 (12) |
| Mean CHA2DS2-VASc score (SD) | 2.9 (1.8) | 0.4 (0.5)† | 1 (0) | 2 (0) | 4.1 (1.2) |
Data are n (%) unless indicated otherwise.
*Patients can have had one or more comorbidities from each entity.
†Contribution from female sex category.
IQR: Interquartile range.
SD: Standard deviation.