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. 2016 Jun 6;6:27287. doi: 10.1038/srep27287

Figure 2. Fusion of vNDs with tCells elicits whole-cell currents.

Figure 2

(a) Schematic of the setup. A tCell is voltage-clamped at −70 mV in the whole-cell configuration and vNDs are puffed nearby from a pipette. (b) Fusion of vNDs elicited whole-cell currents that were much larger than the unitary fusion pore currents obtained in the cell-attached configuration depicted in Fig. 1. Application of vNDs in the presence of TeNT did not elicit appreciable currents. (c) Whole-cell charge transfer that resulted from application of vNDs alone, or vNDs in the presence of CDV or TeNT. (n = 8, 7, and 4 cells for vND alone, and with CDV and TeNT). (*Indicates p < 0.05, t- test against vND alone.)