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. Author manuscript; available in PMC: 2017 Apr 30.
Published in final edited form as: Chem Commun (Camb). 2016 Apr 4;52(34):5832–5835. doi: 10.1039/c6cc00898d

Fig. 3.

Fig. 3

Predicted and experimental values of Keu and cocrystal solubility advantage (Scc/Sdrug) for 1:1 NVP-MLE and 2:1 NVP-SAC and NVP-SLC cocrystals. Keu is a key indicator of Scc/Sdrug. Keu dependence on pH reveals the cocrystal pHmax as well as the cocrystal increase in solubility over drug as pH increases. At pHmax, Keu = 1 for 1:1 cocrystals and Keu = 0.5 for 2:1 cocrystals. Log axes are used due to the large range of values. Symbols represent experimental values. Numbers next to data points indicate pH at eutectic point or equilibrium pH. Lines were generated according to equations 5 and 6. Solid lines represent 1:1 cocrystals and dashed lines 2:1 cocrystals.