Scheme 5.
Synthesis of n-butyl-linked α-carboxy nucleoside phosphonate 6h [(i) Pd/C (10%), H2 (1 atm), MeOH, rt, 12 h (ii) a. TMSBr, CH3CN, 0 °C-rt, 16 h, H2O, 1h; b. aq. NaOH, 50 °C, 12 h, charcoal column].
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