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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: J Med Chem. 2015 Oct 9;58(20):8110–8127. doi: 10.1021/acs.jmedchem.5b01180

Table 2.

Generality of the Mitsunobu reaction for attaching the nucleobase

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Reaction conditions: (i) 3 (1.0 equiv.), 4a (1.2 equiv.), PPh3 (2.1 equiv.), DIAD (2.0 equiv.), THF, −40°C-RT, 24h.