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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: J Med Chem. 2015 Oct 9;58(20):8110–8127. doi: 10.1021/acs.jmedchem.5b01180

Table 3.

Deprotection of α-carboxy nucleoside phosphonates 5a–5e to 6a–6e.

graphic file with name nihms784557f14.jpg

Reaction conditions: (i) TMSBr (7.0 equiv) CH3CN, 0 °C-rt, 16 h.(ii) H2O, 30 min, rotary evaporation (iii) aq. NaOH, 50 °C, 12 h and then aq. NH3, charcoal column.