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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: J Med Chem. 2015 Oct 9;58(20):8110–8127. doi: 10.1021/acs.jmedchem.5b01180

Table 8.

Inhibitory activity of acyclic α-CNPs against wild-type and mutant HIV-1 RTs

Nucleobase Compound IC50 (μM)
Wild-type M184I M184V Y115F
Thymine 6g 320 ± 89 >2,500 >2,500 655 ± 409
Adenine 6k 531 ± 154 ≥2,500 >2,500 630 ± 37
Guanine 6l ≥1,250 >1,250 >1,250 ≥1,250
Cytosine 6m 318 ± 73 >1,250 >1,250 408 ± 16