Table I.

List of AF mutations identified in KCNQ1, hERG and Kv1.5 channels.

channel	mutation	location	function	Clinical phenotype	reference
KCNQ1	A46T	N	gain	normal or long QT, AF	[158]
	S140G	S1	gain	normal or long QT, AF	[159, 160]
	V141M	S1	gain	short QT, AF	[160, 161]
	Q147R	S1	loss	long QT, AF	[162]
	R195W	intracellular	gain	normal or long QT, AF	[158]
	S209P	S3	gain	normal QT, AF	[163]
	G229D	S4	gain	normal QT, AF	[164]
	R231C	S4	gain	normal or long QT, AF	[165, 166]
	R231H	S4	gain	normal or long QT, AF	[167]
	V241F	S4	gain	normal QT, AF	[168]
	A302V	pore	loss	long QT, AF	[158]
	R670K	C	gain	normal QT, AF	[158]
HERG	N588K	pore	gain	short QT, AF	[138, 174]
	K897T	C	loss/gain	long or short QT, AF	[169]
Kv1.5	71-81del	N	loss	AF	[155]
	E48G	N	gain	AF	[170]
	Y155C	N	loss	AF	[170]
	A305T	S1–2	gain	AF	[170]
	D322H	S1–2	gain	AF	[170]
	E375X	S4	loss	AF	[171]
	D469E	pore	loss	AF	[170]
	P488S	pore	loss	AF	[170]
	T527M	pore	loss	AF	[172]
	A576V	C	loss	AF	[172]
	E610K	C	loss	AF	[172]

Data from Refs 138,158–172.