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. Author manuscript; available in PMC: 2016 Sep 28.

Published in final edited form as: Stress. 2015 Sep 28;18(6):668–676. doi: 10.3109/10253890.2015.1087502

Body temperature (sc) during cold exposure after serotonin 2A/C receptor agonist DOI injection into the mPOA. Data were analyzed at basal, 30 and 60 min time points in the cold room. A) 4 days after last stressor, DOI was injected 20 min before rats were placed in a cold room and body temperature was recorded. Stress+DOI significantly increased body temperature at 30 min compared to NoStress+aCSF, NoStress+DOI and Stress+aCSF (*, p < 0.05) and at 60 min was significantly different from Stress+aCSF (#, p < 0.05). B) NoStress controls and Stress+DOI treated rats elevated their sc. body temperatures from basal levels in response to cold room exposure 4 days after last stressor. Stress+aCSF treatment significantly decreased body temperature in the cold room compared to all other groups and DOI treatment in Stress rats prior to cold room blocked this effect. (*, p < 0.01, Stress+aCSF vs. all other groups at 60 min; &, p < 0.01; Stress+aCSF vs. Stress+DOI at 30 min; #, p < 0.05, Stress+DOI, NoStress+DOI and NoStress+aCSF at 60 min vs. basal) (n = 5–6 per group).

Body temperature (sc) during cold exposure after serotonin 2A/C receptor agonist DOI injection into the mPOA. Data were analyzed at basal, 30 and 60 min time points in the cold room. A) 4 days after last stressor, DOI was injected 20 min before rats were placed in a cold room and body temperature was recorded. Stress+DOI significantly increased body temperature at 30 min compared to NoStress+aCSF, NoStress+DOI and Stress+aCSF (*, p < 0.05) and at 60 min was significantly different from Stress+aCSF (#, p < 0.05). B) NoStress controls and Stress+DOI treated rats elevated their sc. body temperatures from basal levels in response to cold room exposure 4 days after last stressor. Stress+aCSF treatment significantly decreased body temperature in the cold room compared to all other groups and DOI treatment in Stress rats prior to cold room blocked this effect. (*, p < 0.01, Stress+aCSF vs. all other groups at 60 min; &, p < 0.01; Stress+aCSF vs. Stress+DOI at 30 min; #, p < 0.05, Stress+DOI, NoStress+DOI and NoStress+aCSF at 60 min vs. basal) (n = 5–6 per group).