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. 2016 Jun 2;7:2041731416652778. doi: 10.1177/2041731416652778

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Cells fixed after 3 days showing actin (cytoskeleton), vinculin (adhesion) and RUNX2 (osteoblastic transcription factor) staining. Vinculin formed large, distinct adhesion complexes at the peripheries of cells particularly on the 80-nm-deep features and the other topographies compared to control. Concomitantly, actin stress fibres were also more organised. RUNX2 had increased nuclear and cytoplasmic concentrations on the topographies compared with controls (arrows indicate nuclear localisation and arrowheads indicate cytoplasmic localisation).