Table 1.
Physical and hormonal characteristics of metabolically healthy obese PCOS (MHO-PCOS) girls and metabolically unhealthy obese (MUHO-PCOS) girls in the total cohort.
| Variables | MHO-PCOS (n=19) |
MUHO-PCOS (n=51) |
P |
Adjusted * P |
|---|---|---|---|---|
| Age (years) | 16.0 ± 0.3 | 14.9 ± 0.3 | 0.065 | |
| Race (AA/AW/Bi) | 2(11%)/13(68%)/4(21%) | 17(33%)/32(63%)/2(4%) | 0.024 | |
| Tanner stage (IV/V) | 0 (0%) / 19 (100%) | 9 (17%) / 42 (83%) | 0.050 | |
| Glycemic status (NGT/IGT) | 14 (74%) / 5 (26%) | 28 (55%) / 23 (45%) | NS | |
| Anthropometrics | ||||
| BMI (kg/m2) | 33.3 ± 0.9 | 38.4 ± 0.2 | 0.007 | <0.0001 |
| BMI percentile | 96.8 ± 0.4 | 98.5 ± 0.2 | <0.0001 | <0.0001 |
| Fat mass (kg) | 40.8 ± 2.2 | 46.6 ± 2.1 | NS | 0.006 |
| Percent body fat (%) | 45.3 ± 0.8 | 46.6 ± 0.7 | NS | 0.123 |
| Fat free mass (kg) | 45.3 ± 1.5 | 49.3 ± 1.1 | 0.053 | <0.0001 |
| Waist circumference (cm) | 97.0 ± 3.2 | 110.2 ± 3.5 | 0.011 | 0.012 |
| Hip circumference (cm) | 113.1 ± 2.4 | 125.9 ± 3.1 | 0.005 | 0.005 |
| VAT (cm2) | 59.1 ± 4.3 | 84.8 ± 5.1 | 0.023 | 0.001 |
| SAT (cm2) | 512.9 ± 28.0 | 612.0 ± 26.9 | 0.051 | 0.003 |
| TAT (cm2) | 572.0 ± 30.1 | 696.7 ± 29.3 | 0.016 | <0.0001 |
| Sex steroid hormonal profile | ||||
| Total testosterone (ng/dL) | 36.2 ± 3.7 | 41.2 ± 2.9 | NS | NS |
| SHBG (nmol/L) | 30.6 ± 3.9 | 18.6 ± 1.4 | <0.001 | 0.002# |
| Free testosterone (pg/mL) | 6.5 ± 1.0 | 9.7 ± 0.9 | 0.013 | 0.003# |
| Estradiol (pg/mL) | 84.2 ± 16.8 | 56.3 ± 6.0 | 0.045 | 0.038# |
| DHEAS (ug/dL) | 197.6 ± 20.7 | 201.0 ± 19.2 | NS | NS |
| Adipokines and inflammatory markers | ||||
| Leptin (ng/mL) | 33.4 ± 2.4 | 43.2 ± 2.8 | 0.027 | 0.042 |
| Adiponectin (ug/mL) | 6.6 ± 0.6 | 5.5 ± 0.3 | NS | 0.095 |
| Leptin/Adiponectin ratio | 5.5 ± 0.5 | 9.3 ± 0.9 | 0.004 | 0.002# |
| hs-CRP (mg/L) | 0.9 ± 0.2 | 2.5 ± 0.5 | 0.013 | 0.007 |
Values are mean ± SEM, or n (%) / n (%) unless otherwise indicated.
*
P adjusted for race and Tanner stage.
#
indicates P <0.01 after adjusting for BMI in addition to race and Tanner stage.
NS, not-significant; AA, African-American; AW, American-White; Bi, biracial; NGT, normal glucose tolerance; IGT, impaired glucose tolerance; BMI, body mass index; VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue; TAT, total adipose tissue; SHBG, sex hormone-binding globulin; DHEAS, dehydroepiandrosterone sulfate.