Table 3.
Pair-matched metabolically healthy obese (MHO-PCOS) and metabolically unhealthy obese PCOS (MUHO-PCOS) girls for BMI and age; physical, hormonal and metabolic characteristics.
| Variables | MHO-PCOS (n=19) |
MUHO-PCOS (n=19) |
P |
|---|---|---|---|
| Age (years) | 16.0 ± 0.3 | 15.7 ± 0.4 | NS |
| Race (AA/AW/Bi) | 2(11%)/13(68%)/4(21%) | 5(26%)/13(68%)/1(5%) | NS |
| Tanner stage (IV/V) | 0 (0%) / 19 (100%) | 1 (5%) / 18 (95%) | NS |
| Glycemic status (NGT/IGT) | 14 (74%) / 5 (26%) | 11 (58%) / 8 (42%) | NS |
| Anthropometrics | |||
| BMI (kg/m2) | 33.3 ± 0.9 | 34.1 ± 0.9 | NS |
| BMI percentile | 96.8 ± 0.4 | 97.8 ± 0.4 | NS |
| Fat mass (kg) | 40.8 ± 2.2 | 40.4 ± 1.7 | NS |
| Percent body fat (%) | 45.3 ± 0.9 | 44.8 ± 0.9 | NS |
| Waist circumference (cm) | 97.0 ± 3.2 | 101.0 ± 3.6 | NS |
| VAT (cm2) | 59.2 ± 4.3 | 87.7 ± 7.7 | 0.003 |
| SAT (cm2) | 513.0 ± 28 | 537.5 ± 34 | NS |
| TAT (cm2) | 572 ± 30.1 | 625.1 ± 37.8 | NS |
| Sex steroid hormonal profile | |||
| Total testosterone (ng/dL) | 36.2 ± 3.7 | 46.8 ± 6.1 | NS |
| SHBG (nmol/L) | 30.6 ± 3.8 | 19.5 ± 2.8 | 0.009 |
| Free testosterone (pg/mL) | 6.5 ± 1.0 | 11.6 ± 2.1 | 0.018 |
| Estradiol (pg/mL) | 84.2 ± 16.8 | 51.1 ± 6.4 | 0.051 |
| DHEAS (ug/dL) | 197.6 ± 20.7 | 201.0 ± 19.2 | NS |
| Adipokines and inflammatory markers | |||
| Leptin (ng/mL) | 33.4 ± 2.4 | 35.7 ± 2.7 | NS |
| Adiponectin (ug/mL) | 6.6 ± 0.6 | 5.3 ± 0.3 | 0.059 |
| Leptin/Adiponectin ratio | 5.5 ± 0.5 | 7.0 ± 0.5 | 0.047 |
| hs-CRP (mg/L) | 0.9 ± 0.2 | 1.3 ± 0.2 | NS |
| Traditional lipid profile | |||
| Total cholesterol (mg/dL) | 143.4 ± 6.6 | 165.1 ± 8.1 | 0.038 |
| VLDL (mg/dL) | 22.9 ± 2.8 | 24.8 ± 2.5 | 0.016 |
| Lipoprotein Particle Concentration | |||
| Large VLDL (nmol/L) | 2.5 ± 1.1 | 3.4 ± 0.6 | 0.040 |
| Medium-small LDL (nmol/L) | 93.6 ± 17.9 | 131.3 ± 16.2 | 0.047 |
| Very small LDL (nmol/L) | 332.0 ± 54.1 | 504.3 ± 74.3 | 0.032 |
Values are mean ± SEM, or n (%) / n (%) unless otherwise indicated. NS, not-significant.