A) Mean (+/− SEM) number of licks/5 min of 0.15% saccharin during Trial 1 and Trial 16 for Saline, Small, and Large Suppressors. Mean (+/− SEM) number of saline or heroin (0.06 mg/0.2ml of heroin) infusions/6 h B) and C) within in the 1st h for Saline, Small, and Large Suppressors during Trial 1 and Trial 16. D) Mean (+/− SEM) number of saline or heroin infusions earned during progressive ratio testing for Saline, Small, and Large Suppressors. E) Mean (+/− SEM) number of drug seeking behaviors/1 h exhibited during Hour 1 of the 6 h extinction period (left panel) and during 1 h following a single experimenter delivered iv dose of saline or heroin for Saline, Small, and Large Suppressors. *p<0.05 (n=5/group)