Table 2.
Dark Cytotoxicity, Photocytotoxicity (1.5 J/cm2), and Uptake Plateau Concentration of BODIPYs in Human Glioma T98G Cells, Permeabilty Coefficients (Pe) of BODIPYs and Lucifer Yellow (LY) in Human Endothelial hCMEC/D3 Cells, and Octanol–Water Partition Coefficients (log P) of BODIPYs
| compd | MW (g/mol) | log P | dark cytotoxicity, IC50 (μM) | phototoxicity, IC50 (μM) | cellular uptake at 24 h (nM/cell) | Pe × 10−5 (cm/s) |
|---|---|---|---|---|---|---|
| LY | 457.24 | 2.2 ± 0.8 | ||||
| 1b | 366.25 | 1.50 | >100 | >100 | 0.23 ± 0.05 | 16.4 ± 3.3 |
| 2b | 394.31 | 1.69 | >100 | 98 | 0.36 ± 0.03 | 6.0 ± 1.0 |
| 3b | 422.36 | 1.73 | >100 | 80 | 0.11 ± 0.02 | 4.4 ± 0.5 |
| 4a | 438.33 | 2.11 | >100 | >100 | 0.41 ± 0.03 | |
| 5b | 450.41 | 1.95 | >100 | 40 | 1.5 ± 0.05 | 2.6 ± 0.9 |
| 6b | 484.85 | 1.93 | >100 | >100 | 0.46 ± 0.06 | 5.4 ± 0.6 |
| 7a | 526.50 | 2.70 | >100 | >100 | 0.0034 ± 0.0004 |
a
The Pe values were not determined for these compounds due to their limited solubility in buffer.