Figure 6. PGE2 is required for enhanced SOCS3 secretion during LPS treatment in vivo.
(A) PGE2 levels in BALF 24 h after oropharyngeal administration of LPS (2.5 μg/mouse) to wild type mice, as determined by ELISA. (B) SOCS3 levels in BALF 24 h after oropharyngeal administration of LPS in wild type mice pretreated or not with 1.5 mg/kg indomethacin. (C) SOCS3 levels in BALF 24 h after oropharyngeal administration of LPS to mPGEs-1 KO mice. Data are expressed as mean ± SEM, n= 5 mice per group, *= p<0.05.