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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Card Fail. 2016 Mar 17;22(6):417–422. doi: 10.1016/j.cardfail.2016.03.005

Table 2.

Cox Proportional Hazards Model for Composite Endpoint

Univariate Multivariate
n/N Hazard Ratio
(Unit)		 Lower
95%		 Higher
95%		 P value n/N Hazard Ratio
(Unit)		 Lower
95%		 Higher
95%		 P value
eGFR (mL/min) 34/113 0.990 0.976 1.004 .171 29/104 0.997 0.981 1.013 .726
HR (bpm) 34/119 1.029 1.003 1.053 .030 29/104 1.042 1.010 1.074 .011
LVEF (%) 31/114 0.943 0.905 0.980 .002 29/104 0.969 0.930 1.004 .083
β1AR-AAb status (neg./non-IgG3/IgG3) 35/120 .038 29/104 .021
  Non-IgG3(+) vs neg. 1.751 0.764 3.682 .175 2.180 0.913 4.873 .078
  IgG3(+) vs neg. 0.412 0.120 1.080 .07 0.358 0.080 1.123 .081
  IgG3(+) vs non-IgG3(+) 0.236 0.064 0.725 .011 0.164 0.034 0.597 .005

β1AR-AAb, autoantibody against β1-adrenergic receptor; eGFR, estimated glomerular filtration rate calculated by Modification of Diet in Renal Disease formula; HR, heart rate; LVEF, left ventricular ejection fraction; n, number of patients with endpoints; N, number patients with baseline condition.