Table 2.

The protocol for administering the edrophonium challenge test in patients with movement disorders.

EVALUATION OF PATIENT SYMPTOMS

1. Videotape (1 min) recording of objective symptoms before injection

2. Normal saline injection

3.2 min after injection: videotape recording

4.4 min after injection: videotape recording

5.6 min after injection: videotape recording

6.8 min after injection: videotape recording

7.10 min after injection: videotape recording

8. Visual analog scale (VAS) test (evaluation after normal saline injection)

9. Edrophonium injection

10.2 min after injection: videotape recording

11.4 min after injection: videotape recording

12.6 min after injection: videotape recording

13.8 min after injection: videotape recording

14.10 min after injection: videotape recording

15. VAS test (evaluation after edrophonium injection)

EVALUATION OF THE VIDEO BY THREE MOVEMENT DISORDER SPECIALISTS

1. We chose videos of the isotonic sodium chloride solution and edrophonium injections, randomly referred to as A or B

2. We chose the video acquired at 8 min after administration as A or B Because the symptoms changed the most around 8 min after edrophonium administration

3. The before injection video is shown

4. The after A injection video is shown

5. Modified VAS (the value of after A injection with before injection as midline)

6. The before injection video is shown

7. The after B injection video is shown

8. Modified VAS (the value of after B injection with before injection as midline) We evaluated “before and after A or B injection” as a set, as described above We randomly presented “before and after A or B injection” videos of blepharospasm and hemifacial spasm