Table 2.
Correlation between hypermethylation in DNA repair genes and clinicopathological characteristics of 102 gastric cancer cases
| Clinicopathological parameters (n) | Frequency of methylation, n (%) |
|||
|---|---|---|---|---|
| CHFR | MLH1 | MGMT | RASSFA1 | |
| Gender | ||||
| Male (72) | 24 (33.3) | 19 (26.4) | 4 (5.6) | 9 (12.5) |
| Female (30) | 11 (36.7) | 3 (10.0) | 6 (20.0) | 4 (13.3) |
| p | 0.747 | 0.067 | 0.061 | 1.000 |
| Age (years) | ||||
| n < 60 (73) | 26 (35.6) | 14 (19.2) | 9 (12.3) | 9 (12.3) |
| n ≥ 60 (29) | 9 (31.0) | 8 (27.6) | 1 (3.4) | 4 (13.8) |
| p | 0.660 | 0.352 | 0.321 | 1.000 |
| Tumor histology | ||||
| Intestinal type (64) | 22 (34.3) | 13 (20.3) | 7 (10.9) | 7 (10.9) |
| Diffused and mixed type (33) | 13 (34.2) | 9 (23.6) | 3 (7.9) | 6 (15.8) |
| p | 0.938 | 0.638 | 0.646 | 1.445 |
| Differentiation | ||||
| Well and moderately differentiated (29) | 9 (31.0) | 3 (10.3) | 3 (17.6) | 1 (5.9) |
| Poorly differentiated (73) | 26 (35.6) | 19 (26.0) | 7 (8.2) | 12 (14.1) |
| p | 0.660 | 0.082 | 0.457 | 0.595 |
| Tumor size | ||||
| d < 5 (45) | 13 (28.9) | 12 (26.7) | 5 (11.1) | 4 (8.9) |
| d ≥ 5 (57) | 22 (38.6) | 10 (17.5) | 5 (8.8) | 9 (15.8) |
| p | 0.305 | 0.266 | 0.953 | 0.299 |
| Tumor invasion | ||||
| T1–T2 (13) | 7 (53.8) | 3 (23.1) | 2 (15.4) | 1 (7.7) |
| T3–T4 (89) | 28 (31.5) | 19 (21.3) | 8 (9.0) | 12 (13.5) |
| p | 0.112 | 0.887 | 0.822 | 0.889 |
| Lymph node metastasis | ||||
| N0–N1 (36) | 10 (27.8) | 10 (27.8) | 2 (5.6) | 4 (11.1) |
| N1–N3 (66) | 25 (37.9) | 12 (18.2) | 8 (12.5) | 9 (14.3) |
| p | 0.304 | 0.260 | 0.473 | 0.956 |
| Peritoneal or distant metastasis | ||||
| M0 (94) | 30 (31.9) | 21 (22.3) | 8 (8.5) | 11 (11.7) |
| M1 (8) | 5 (62.5) | 1 (12.5) | 2 (25) | 2 (25) |
| p | 0.080 | 0.516 | 0.375 | 0.596 |
| Tumor stage | ||||
| I–II (19) | 6 (31.6) | 6 (31.6) | 2 (10.5) | 3 (15.8) |
| III–IV (83) | 29 (34.9) | 16 (19.3) | 8 (9.6) | 10 (12.0) |
| p | 0.781 | 0.240 | 0.100 | 0.952 |
| Vessel invasion | ||||
| Negative (72) | 25 (34.7) | 15 (20.8) | 9 (12.5) | 9 (12.5) |
| Positive (30) | 10 (33.3) | 7 (23.3) | 1 (3.3) | 4 (13.3) |
| p | 0.893 | 0.780 | 0.292 | 1.000 |
Pathological tumor invasion, lymph node status, distant metastasis status, and TNM stage of gastric cancer were evaluated according to American Joint Committee on Cancer (AJCC), 7th edition, 2009. Statistical analysis was performed by χ2 or Fisher exact test
p < 0.05 was considered statistically significant