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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: Adv Exp Med Biol. 2012;710:107–133. doi: 10.1007/978-1-4419-5638-5_11

Table 11.1.

Classification of HDACs and selected HDACI

HDAC class HDAC isoforms Localization of HDAC Specific HDAC inhibitors Non-specific HDAC
inhibitors
References
Class I
(Zn++ – dependent)
HDAC1 Nucleus MS-275, FK-228 TSA Chuang et al. (2009), Lane and Chamber (2009)
HDAC2 Nucleus FK-228, apicidin SAHA
HDAC3 Nucleus MS-275, apicidin Butyrate
HDAC8 Nucleus Valproic acid
Class IIa
(Zn++-dependent)
HDAC4 Nuc/Cyt TSA Chuang et al. (2009), Lane and Chamber (2009)
HDAC5 Nuc/Cyt SAHA
HDAC7 Nuc/Cyt Butyrate
HDAC9 Nuc/Cyt Valproic acid
Class IIb
(Zn++-dependent)
HDAC6 Mainly Cyt Tubacin TSA Lane and Chamber (2009)
HDAC10 Mainly Cyt SAHA
Class III
(NAD+-dependent)
SIRT1 Nuc/Cyt Suramin Nicotinamide Chuang et al. (2009), Suzuli (2009), Scher et al. (2007)
SIRT2 Nuc/Cyt Suramin, AGK2
SIRT3 Nuc/Mitoch
SIRT4 Mitochondria
SIRT5 Mitochondria
SIRT6 Nucleus
SIRT7 Nucleus
Class IV
(Zn++-dependent)
HDAC11 Nuc/Cyt TSA Lane and Chamber (2009)
SAHA