Table 11.1.
HDAC class | HDAC isoforms | Localization of HDAC | Specific HDAC inhibitors | Non-specific HDAC inhibitors |
References |
---|---|---|---|---|---|
Class I (Zn++ – dependent) |
HDAC1 | Nucleus | MS-275, FK-228 | TSA | Chuang et al. (2009), Lane and Chamber (2009) |
HDAC2 | Nucleus | FK-228, apicidin | SAHA | ||
HDAC3 | Nucleus | MS-275, apicidin | Butyrate | ||
HDAC8 | Nucleus | Valproic acid | |||
Class IIa (Zn++-dependent) |
HDAC4 | Nuc/Cyt | TSA | Chuang et al. (2009), Lane and Chamber (2009) | |
HDAC5 | Nuc/Cyt | SAHA | |||
HDAC7 | Nuc/Cyt | Butyrate | |||
HDAC9 | Nuc/Cyt | Valproic acid | |||
Class IIb (Zn++-dependent) |
HDAC6 | Mainly Cyt | Tubacin | TSA | Lane and Chamber (2009) |
HDAC10 | Mainly Cyt | SAHA | |||
Class III (NAD+-dependent) |
SIRT1 | Nuc/Cyt | Suramin | Nicotinamide | Chuang et al. (2009), Suzuli (2009), Scher et al. (2007) |
SIRT2 | Nuc/Cyt | Suramin, AGK2 | |||
SIRT3 | Nuc/Mitoch | ||||
SIRT4 | Mitochondria | ||||
SIRT5 | Mitochondria | ||||
SIRT6 | Nucleus | ||||
SIRT7 | Nucleus | ||||
Class IV (Zn++-dependent) |
HDAC11 | Nuc/Cyt | TSA | Lane and Chamber (2009) | |
SAHA |