. Author manuscript; available in PMC: 2016 Jun 6.

Published in final edited form as: J Biomed Mater Res A. 2014 Mar 3;102(12):4568–4580. doi: 10.1002/jbm.a.35122

TABLE I.

Study Design

Time Point (weeks)	Defect Side^a	Treatment		Treatment Code
Time Point (weeks)	Defect Side^a	BMSCs	BMP-2	Treatment Code
4	Right	−	+	H+BMP
	Left	−	−	H−BMP
8	Right	−	+	H+BMP
	Left	−	−	H−BMP
4	Right	+	+	H+C+BMP
	Left	+	−	H+C−BMP
8	Right	+	+	H+C+BMP
	Left	+	−	H+C−BMP

Direction of the defects has been defined with respect to the reader for easier interpretation.

No. of BMSCs implanted: 1 × 10⁶ per defect.

Amount of BMP implanted: 2 μg per defect.