Table 1. Top association results for the linear models run for DSM-5 cocaine use disorder. Bolded SNPs passed multiple test correction (p > 0.002). Maximum FTND is the score from 0–10, L95 and U95 is the 95% confidence interval, and the frequency is in the SAGE dataset.
| European-Americans SAGE DSM-5 Cocaine Use Disorder with covariates age, sex, maximum FTND score, DSM-5 alcohol symptom count, study | ||||||||
|---|---|---|---|---|---|---|---|---|
| SNP | LD Bin | bp | N | OR | L95 | U95 | Freq | P |
| rs9298626 | 1 | 42,647,165 | 1970 | 2.62 | 1.57 | 4.37 | 0.04 | 2.34E-04 |
| rs7844824 | 1 | 42,672,170 | 1970 | 2.65 | 1.58 | 4.46 | 0.04 | 2.43E-04 |
| rs4305884 | 2 | 42,637,880 | 1966 | 2.13 | 1.42 | 3.21 | 0.06 | 2.69E-04 |
| rs7824160 | 1 | 42,705,413 | 1969 | 2.50 | 1.49 | 4.19 | 0.04 | 4.88E-04 |
| rs11986893 | 4 | 42,772,016 | 1971 | 1.56 | 1.22 | 2.01 | 0.2 | 4.92E-04 |
| rs7002907 | 1 | 42,702,998 | 1970 | 2.49 | 1.49 | 4.17 | 0.04 | 5.03E-04 |
| rs6997994 | 1 | 42,702,328 | 1971 | 2.49 | 1.49 | 4.18 | 0.04 | 5.04E-04 |
| rs7815274 | 1 | 42,701,740 | 1967 | 2.47 | 1.47 | 4.15 | 0.04 | 6.41E-04 |
| rs4952 | 1 | 42,706,222 | 1971 | 2.43 | 1.44 | 4.08 | 0.04 | 8.12E-04 |
| rs10107450 | 5 | 42,749,052 | 1969 | 1.50 | 1.18 | 1.92 | 0.22 | 1.04E-03 |
| rs1868859 | 2 | 42,634,958 | 1971 | 1.85 | 1.27 | 2.69 | 0.07 | 1.36E-03 |
| rs892413 | 3 | 42,733,535 | 1971 | 1.48 | 1.15 | 1.89 | 0.2 | 2.11E-03 |
| rs4950 | 6 | 42,671,790 | 1957 | 1.42 | 1.11 | 1.83 | 0.22 | 5.93E-03 |
| rs13280604 | 6 | 42,678,743 | 1971 | 1.41 | 1.10 | 1.80 | 0.22 | 7.49E-03 |
| rs1530848 | 6 | 42,672,065 | 1964 | 1.40 | 1.09 | 1.79 | 0.22 | 7.53E-03 |
| rs2196128 | 3 | 42,737,443 | 1971 | 1.37 | 1.08 | 1.74 | 0.23 | 8.83E-03 |
| rs6997909 | 6 | 42,679,406 | 1971 | 1.39 | 1.08 | 1.78 | 0.22 | 9.67E-03 |
| rs6474414 | 6 | 42,679,493 | 1971 | 1.39 | 1.08 | 1.78 | 0.22 | 9.67E-03 |
| rs4736835 | 6 | 42,666,190 | 1971 | 1.39 | 1.08 | 1.78 | 0.22 | 1.03E-02 |
| rs9298628 | 3 | 42,725,148 | 1968 | 1.38 | 1.08 | 1.76 | 0.21 | 1.04E-02 |
| rs6474415 | 6 | 42,682,095 | 1970 | 1.38 | 1.08 | 1.77 | 0.22 | 1.05E-02 |
| rs1451240 | 6 | 42,665,868 | 1970 | 1.38 | 1.08 | 1.77 | 0.22 | 1.14E-02 |
| rs7004381 | 6 | 42,670,318 | 1971 | 1.38 | 1.07 | 1.77 | 0.22 | 1.24E-02 |
| rs13273442 | 6 | 42,663,174 | 1970 | 1.38 | 1.07 | 1.77 | 0.22 | 1.25E-02 |
| rs1955185 | 6 | 42,668,804 | 1971 | 1.37 | 1.07 | 1.76 | 0.22 | 1.30E-02 |
| rs6474413 | 6 | 42,670,221 | 1971 | 1.37 | 1.07 | 1.76 | 0.22 | 1.31E-02 |
| rs16891620 | 7 | 42,744,820 | 1970 | 1.42 | 1.06 | 1.92 | 0.13 | 2.00E-02 |
| rs10958726 | 6 | 42,655,066 | 1971 | 1.34 | 1.04 | 1.73 | 0.21 | 2.20E-02 |
| rs6474421 | 12 | 42,776,255 | 1969 | 1.50 | 1.05 | 2.14 | 0.07 | 2.62E-02 |
| rs10958725 | 6 | 42,643,741 | 1968 | 1.31 | 1.02 | 1.68 | 0.22 | 3.37E-02 |
| rs7012713 | 13 | 42,711,460 | 1970 | 1.65 | 1.01 | 2.70 | 0.04 | 4.66E-02 |