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. 2015 Mar 10;5:8902. doi: 10.1038/srep08902

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(a) ARI inhibited PRL release in all concentrations tested (0.1, 0.5 and 1 μM) and the subsequent application of 1 μM DA further down-regulated hormone release. (b) PAL alone slightly increased PRL release and blocked the inhibitory effect of 1 μM DA on hormone release in a concentration dependent manner; PAL was used at concentrations of 0, 0.1, 0.5, and 1 μM, as indicated. (c) ARI inhibited PRL secretion to comparable levels as DA, whereas DA was unable to inhibit PRL release in the presence of PAL (closed circles); PAL was able to reverse DA inhibitory action with a transient overshot (open circles). All drugs were applied at a 1 μM concentration. The vertical dotted line indicates the moment of switch in drug application as indicated above the line.