Figure 1. A cartoon depicting the time-line of various experiments.

A cohort of 21-months old rats was examined using a water maze test (WMT) and animals with normal spatial learning and memory function were chosen and divided into two groups. One of the groups then received vehicle (VEH, n = 7) and the other group received resveratrol (RESV, n = 8) for four weeks. Animals in both groups also received 5′-bromodeoxyuridine (BrdU) in the last week of VEH or RESV treatment to facilitate the labeling and quantification of newly born cells and neurons. Both groups underwent a second WMT four weeks after the termination of VEH or RESV treatment followed by a forced swim test (FST). Animals were next euthanized via intracardiac perfusions and brain tissues processed for immunohistochemical staining and various quantifications.