. 2014 Dec 17;4:7513. doi: 10.1038/srep07513

Table 3. A summary of genes clustered with high enrichment using Gene functional annotation via DAVID. Worm annotations were obtained from WormBase⁴⁷.

Gene Group 1	Enrichment Score: 21.4
Official gene symbol	Function
unc-30(UNCoordinated)	homeodomain-containing proteiṅ orthologous to the Pitx family of homeodomain transcription factorṡ controls the terminal differentiation of all 19 type D GABA-ergic motor neurons during development
skn-1(SKiNhead)	bZip transcription factor orthologous to the mammalian Nrf (Nuclear factor-erythroid-related factor) transcription factorṡ required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells during early embryogenesiṡ functions in the p38 MAPK pathway to regulate the oxidative stress response and in parallel to DAF-16/FOXO in the DAF-2-mediated insulin/IGF-1-like signaling pathway to regulate adult lifespan
nhr-49(Nuclear Hormone Receptor family)	nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRṡ key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectivelẏ activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts
fos-1(FOS B-Zip transcription factor homolog)	encodes two basic region-leucine zipper (bZip) transcription factors, FOS-1A and FOS-1B, that are the sole C. elegans ortholog of the fos bZip transcription factor familẏ required cell autonomously in the gonadal anchor cell for basement-membrane removal and subsequent anchor cell invasion of the vulval epithelium
nfi-1(Nuclear Factor I family)	encodes the C. elegans ortholog of the Nuclear Factor I (NFI) family of transcription factors in C. elegans ˙ required for locomotion, egg laying, pharyngeal pumping, and wild-type adult lifespan
vab-3(Variable ABnormal morphology)	homeodomain protein (Pax-6 ortholog)˙ required for proper patterning of anterior (head) hypodermal cellṡ required for epidermal morphogenesis, epidermal cell fates, gonad cell migration and the development of sensory structures in the male tail

Table 3. A summary of genes clustered with high enrichment using Gene functional annotation via DAVID. Worm annotations were obtained from WormBase47.

Table 3. A summary of genes clustered with high enrichment using Gene functional annotation via DAVID. Worm annotations were obtained from WormBase⁴⁷.