Table 1. Genes showing strongest upregulation in each phase of epileptogenesis and in all three phases (left 3 gene columns) The 20 genes with the largest increases in expression that were unique to each time point. (right gene column) The 20 genes common to all three time points with the largest increases in expression relative to control tissue. (FC = Fold Change; q = q-value).
| 12 Hours | 10 Days | 6 Weeks | FC; q | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Genes | FC; q | Genes | FC; q | Genes | FC; q | Genes | 12 Hours | 10 Days | 6 Weeks |
| Nt5c3l | 240; 0.020 | Pdlim2 | 367; <0.001 | Pggt1b | 269; <0.001 | Ralgps1 | 38; <0.001 | 51; <0.001 | 102; <0.001 |
| Dusp22 | 185; <0.001 | Lbp | 234; 0.030 | Spag6 | 221; <0.001 | Afg3l1 | 70; <0.001 | 63; <0.001 | 80; <0.001 |
| Paqr9 | 161; <0.001 | Lgals9 | 193; <0.001 | Naip2 | 190; <0.001 | Elf1 | 145; <0.001 | 62; 0.021 | 69; 0.005 |
| H2-Ke2 | 157; <0.001 | 2310009B15Rik | 168; <0.001 | Gpnmb | 179; <0.001 | Cxcl12 | 61; <0.001 | 45; 0.001 | 66; <0.001 |
| Ift27 | 155; 0.005 | Echdc2 | 166; <0.001 | BC067068 | 141; <0.001 | Tmem186 | 164; <0.001 | 46; 0.033 | 48; 0.046 |
| Dusp14 | 151; <0.001 | Cd72 | 153; <0.001 | Rsad1 | 140; 0.003 | Notch3 | 23; <0.001 | 62; 0.013 | 43; <0.001 |
| Wdr46 | 121; <0.001 | Prrg2 | 153; <0.001 | Dysf | 138; <0.001 | Atf7 | 46; 0.002 | 121; <0.001 | 41; <0.001 |
| 2810030E01Rik | 119; <0.001 | Pigw | 152; <0.001 | Sco1 | 135; <0.001 | Mul1 | 63; <0.001 | 84; <0.001 | 39; <0.001 |
| Grin2d | 110; <0.001 | Cbfb | 151; 0.001 | Hpgds | 127; 0.004 | Cflar | 47; <0.001 | 144; <0.001 | 35; <0.001 |
| Fam184b | 109; <0.001 | Adpgk | 150; <0.001 | Il10ra | 127; 0.010 | Ftl1 | 68; <0.001 | 126; <0.001 | 34; <0.001 |
| Tekt5 | 105; 0.040 | Rnps1 | 147; <0.001 | Samd10 | 127; <0.001 | Zfp143 | 70; 0.002 | 53; <0.001 | 33; <0.001 |
| Spag1 | 103; <0.001 | Mgst1 | 144; <0.001 | Ikbip | 111; <0.001 | Gramd3 | 17; 0.010 | 167; <0.001 | 37; <0.001 |
| Yars2 | 103; <0.001 | Sat1 | 142; 0.030 | Cxcr4 | 110; 0.030 | Fam20a | 24; <0.001 | 17; <0.001 | 47; <0.001 |
| Prss36 | 101; <0.001 | Dolk | 137; <0.001 | Spint1 | 108; <0.001 | Lass2 | 10; <0.001 | 89; <0.001 | 46; 0.002 |
| Glt1d1 | 101; 0.030 | S100a13 | 135; <0.001 | Gulp1 | 108; <0.001 | C4b | 20; <0.001 | 42; <0.001 | 63; <0.001 |
| Wdr60 | 98; 0.003 | Slc16a9 | 132; <0.001 | Fgl2 | 104; <0.001 | Dnaja3 | 65; 0.003 | 27; 0.032 | 57; <0.001 |
| 1110018J18Rik | 97; 0.002 | Gdpd5 | 130; 0.020 | Esam | 103; <0.001 | Fam173a | 89; 0.003 | 60; <0.001 | 14; 0.001 |
| Stap2 | 96; <0.001 | 1190002H23Rik | 124; <0.001 | Trhr2 | 100; <0.001 | Asb7 | 39; 0.041 | 72; 0.002 | 28; <0.001 |
| Slc27a3 | 93; 0.010 | Med30 | 124; <0.001 | Sel1l3 | 99; <0.001 | Ltbp3 | 5; 0.003 | 77; <0.001 | 20; 0.030 |
| Larp6 | 93; 0.004 | Crybb1 | 122; <0.001 | Nol12 | 96; <0.001 | Scyl3 | 14; <0.001 | 63; <0.001 | 11; 0.006 |