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. 2014 Jul 4;4:5577. doi: 10.1038/srep05577

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(A) HL-60[R] cells treated with 12.5 μM ATRA, 1.0 μM doxorubicin, and 0.3 μM VP-16. (B) HL-60 cells treated with 1.0 μM ATRA, 1.0 μM doxorubicin, and 0.3 μM VP-16. Percentage of HL-60 and HL-60[R] cell viability after ATRA (C), doxorubicin (D), and VP-16 (E) treatment, as determined by MTT assay. Flow cytometry analysis of the effect of ATRA on the cellular DNA content of HL-60 and HL-60[R] cells. (F) HL-60 cells without ATRA. (G) HL-60 treated with 1.0 μM ATRA. (H) MDR HL-60[R] cells maintained in 1.0 μM ATRA.