Table 3. Top 5 canonical pathways involving genes that are differently expressed in ATRA- differentiated HL-60 and -resistant HL-60[R] cells, as determined by Ingenuity Pathway Analysis.

Top 5 ATRA pathways	p value	Ratio	Molecules
Resistance
Mismatch repair in eukaryotes	4.75E-05	1.25E-01	FEN1, RFC5, EXO1
DNA double-strand break repair	1.77E-03	1.00E-01	XRCC5, PARP1
Granzyme A signaling	3.27E-03	1.00E-01	NME1, SET
GDP-L-fucose biosynthesis I	9.00E-03	1.43E-01	TSTA3
Nucleotide excision repair pathway	1.09E-02	5.56E-02	POLR2F, GTF2H3
Differentiation
FcY receptor-mediated phagocytosis in macrophages and monocytes	2.01E-03	2.83E-02	MYO5A, PAK1, FGR
L-glutamine biosynthesis II (tRNA-dependent)	5.38E-03	9.09E-02	PET112
Glutamine degradation I	5.38E-03	2.00E-01	GLS
IL-12 signaling and production in macrophages	5.63E-03	1.91E-02	ALB, MYD88, APOC2
Acute phase response signaling	1.06E-02	1.66E-02	KLKB1, ALB, MYD88