Table 2. FAH knockout mice.
Mutant Alleles per Mouse/Total Mice Tested | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Gene | gRNA | Cas9 | Transferred Embryos (Recipients/pregnancies) | Newborns (dead) | 2 indel | 1 indel | 2KI | 1KI | 1indel +1 KI | 0 |
FAH | gRNA3 | WT Nuclease | 211** (8/4) | 11 (2) | 3 | 1 | 1 | 2 | 2 | 0 |
gRNA1 + gRNA3 | D10A Mut Nickase | 147 (6/2) | 11 (1) | 3 | 0 | 0 | 0 | 0 | 7 |
**201 injected embryos were transferred. One recipient received 11 injected and 10 non-injected embryos. This recipient did not produce any births.