Figure 5. Extracellular NA does not activate TRPV2 but strongly inhibits 2-APB-induced current.

(A&B) Representative whole-cell patch-clamp currents of TRPV2 with NA and/or 2-APB applied extracellularly as indicated. (C) 2-APB dose-response curves for TRPV2 without (black) or with (red) 65 mM NA, fitted to a Hill equation with the following parameters (EC₅₀ and slope factor): without NA, 1.43 ± 0.04 mM and 4.09 ± 0.5 (n = 4); with NA, 2.34 ± 0.17 mM and 4.64 ± 0.98 (n = 3).