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A] Objectives of the study - 1] Perform structure-activity relationship (SAR) study by modifying the 1, 3 and 5-positions of the tetramic core 2] Determine selectivity index by measuring cytotoxicity against Vero cells and comparing to MIC against S. aureus Newman strain and 3] Determine the mechanism of action against S. aureus. B] Synthetic scheme for the preparation of the reutericyclin analogs.
