Table 2. Cytotoxicity, hemolytic activity and logD values of reutericyclin analogs.

Number	Cytotox IC50, μg/ml	Selectivity index	Hemolysis EC50, μg/ml	logD, pH 7.4
1	7.46	10	27.87	4.31
2	217.28	1	>200	0.48
3	39.67	1	>200	2.05
4	30.44	2	>200	2.61
5	11.25	14	71.14	4.00
6	5.77	>58	11.72	5.92
7	12.51	>125	21.80	5.85
8	115.86	5	125.09	4.75
9	115.05	2	160.85	2.89
10	14.22	36	61.61	5.33
11	19.80	25	30.27	5.59
12	57.63	9	38.86	5.61
13	13.40	67	32.48	6.06
14	39.93	3	130.91	2.72
15	113.45	1	>200	1.74
16	49.76	1	>200	1.34
17	163.52	1	>200	2.00
18	50.62	8	52.28	4.60
19	93.53	2	80.41	4.67
20	11.50	>115	19.85	5.83

Cytotox IC₅₀ - Concentration which reduces viability of Vero kidney cells by 50%. Selectivity index - Cytotox IC₅₀/MIC against methicillin-susceptible Staphylococcus aureus Newman. Hemolysis EC₅₀ - effective concentration of compound causing a 50% reduction in erythrocytes with intact membranes. The logD values were calculated using Pipeline Pilot v 8.5.